2 edition of effect of glucocorticoids and analogues on the rat thymus found in the catalog.
effect of glucocorticoids and analogues on the rat thymus
Lydia Phindile Makhubu
Written in English
|The Physical Object|
|Pagination||iv, 146 leaves.|
|Number of Pages||146|
INTRODUCTION. Glucocorticoids (corticosteroids) have inhibitory effects on a broad range of immune responses. Because of their inhibitory effects on multiple types of immune cells, glucocorticoids are remarkably efficacious in managing many of the acute disease manifestations of inflammatory and autoimmune disorders .The mechanisms of action of glucocorticoids upon the . The profound lympholytic effect of glucocorticoids on developing thymocytes has been described in depth, however, little is known about the cells that survive long-term glucocorticoid treatment. Figure 1 shows the effect of an in vivo dexamethasone dose on thymus gland size and cell number.
To our knowledge, there are no data regarding differential effects of the two glucocorticoids on ACTH secretion in Syrian hamsters. The data presented here indicate tissue-specific effects of glucocorticoids in a dual secreting model, with cortisol having marked effects on thymus and adrenal gland growth as well metabolic end points. R P McPartland's 25 research works with citations and reads, including: Glucocorticoid activity of various progesterone analogs: correlation between specific binding in thymus and liver.
vivo treatment with glucocorticoids induces 90% cell death of rat thymic cells, mainly immature cells which localise in the thymus cortex. The remaining living cells do not show any sign of apoptosis, indicating that there is a subpopulation resistant to programmed cell death in the thymus, mainly CD-4 and -8 cells . PI. Many of the functional foods are designed to decrease the risk of chronic diseases like osteoporosis (OP) which is the most common bone disorder affecting millions of people. For the first time, the present study evaluated the effect of the combination between the Greek Thymus vulgaris water extract (TVE) and bee's Editors' collection: Food Engineering, Science, Technology, and Nutrition.
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Summary Studies of binding of glucocorticoids to rat thymus cells in vitro demonstrate two forms of binding: (a) Specific binding, which is well correlated with glucocorticoid activity, saturates at high physiological concentrations, and is characterized by slow association and by: Young DA.
Glucocorticoid action on rat thymus cells. Interrelationships between carbohydrate, protein, and adenine nucleotide metabolism and cortisol effects on these functions in vitro.
J Biol Chem. Apr 25; (8)– Nordeen SK, Young DA. Glucocorticoid action on rat thymic by: Dembinski TC, Bell PA. Glucocorticoids modify the rate of ribosomal RNA synthesis in rat thymus cells by regulating the polymerase elongation rate.
J Steroid Biochem. Nov; 21 (5)– Farber JL, Farmar R. Differential effects of cycloheximide on protein and RNA synthesis as a function of dose. Biochem Biophys Res by: Glucocorticoid Action on Rat Thymus Cells II. INTERRELATIONSHIPS BETWEEN RIBONUCLEIC ACID AND PROTEIN METABOLISM AND BE- TWEEN CORTISOL AND SUBSTRATE EFFECTS ON THESE METABOLIC PARAMETERS IN VITRO” DONALD A.
YOUNG (Received for publication, Decem ). Deflazacort is a relatively new glucocorticoid with significant immunosuppressant activity and presumably fewer side effects.
The present study was designed to compare the effects of deflazacort on the proliferative activity of thymus cells and thymolysis with the growth by: 6. Endocrinology 79 () Morita Y. and Munck A.: Effect of glucocortieoids in rioo and in vitro on net glucose uptake and amino acid incorporation by rat thymus cells.
Biochim. hiophys. Acta 93 () Young D. A.: Glucocorticoid action on rat thymus cells. Glucocorticoid receptors Rat thymus Glucocorticoids and thymolytic potency 1. Introduction It is widely accepted that most physiological effects of glucocorticoids result from their specific binding to an intracellular receptor protein in the target organs (Higgins et al., ; Ballard et al., ; Rousseau, ).
The effects of steroids on the binding of [1,H]dexamethasone and [1,H]progesterone to the glucocorticoid receptor of rat thymus cytosol were studied. Although both glucocorticoid agonists and antagonists competed with [1,H]dexamethasone for binding.
Characteristics of the system and effects of glucocorticoids Mol Pharmacol 5: () Gray et al., J.G. Gray, W.B. Pratt, L. Arnonow, Effect of glucocorticoids on hexose uptake by mouse fibroblasts in vitro Biochemistry () Maio and Rickenberg, J.J. Maio, H.V. Rickenberg, Carbohydrate and amino acid transport by.
Ackermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez C, Rossier BC, Loffing J. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule.
Am J Physiol Renal Physiol. ; F–F Addition of corticosteroids produces cytolytic effects in nearly all cells, which are highly specific for those compounds having an 11β-hydroxyl group. Maximum effect occurs at concentrations of cortisol μM, of dexamethasone μM.
Electron microscopy shows marked alteration at 2 hours with nuclear edema and disappearance of the. Munck A, Brinck-Johnsen T. Specific and nonspecific physicochemical interactions of glucocorticoids and related steroids with rat thymus cells in vitro.
J Biol Chem. Nov 10; (21)– Ishii DN, Pratt WB, Aronow L. Steady-state level of the specific glucocorticoid binding component in mouse fibroblasts. Biochemistry. THE hypothesis that the effects of glucocorticoids on certain extrahepatic tissues result from inhibition of glucose utilization was proposed in by Drury1 and Ingle2 in connexion with the.
Our original manuscript, indicating normal T-cell development and selection in the thymus of glucocorticoid receptor (GR)−/− mice 1, and our follow-up viewpoint 2, discussing the controversy surrounding this field, have certainly promoted much discussion.
Recently, we responded to a letter from Ashwell and colleagues 3, and discussed the possible reasons why GR antisense transgenic mice.
Cherry CP, Eisenstein R, Glucksmann A () Epithelial cords and tubules of the rat thymus: effects of age, sex, castration, of sex, thyroid and other hormones on their incidence and secretory activity.
Br J Exp Pathol 90– PubMed Google Scholar. Munck A, Koritz SB () Studies on the mode of action of glucocorticoids in rats. Early effects of cortisol on blood glucose and on glucose entry into muscle, liver and adipose tissue. Biochim Biophys Acta – PubMed CrossRef Google Scholar Following surgical removal of the thymus from an untreated adrenalectomized rat, we have described the effect of glucocorticoids on plasma membrane potential during thymocyte apoptosis and define a sequence of events that places the loss of plasma membrane potential early in the apoptotic pathway following gene expression.
Currently, the. Glucocorticoids, however, not only reduce T cell proliferation, but also lead to another well known effect - glucocorticoid-induced apoptosis. The effect is more prominent in immature T cells still inside in the thymus, but peripheral T cells are also affected.
The exact mechanism regulating this glucocorticoid sensitivity lies in the Bcl-2 gene. Abstract. Glucocorticoids regulate the stress response via a negative feedback control on the brain-pituitary-adrenal axis 1, addition, in the brain glucocorticoids modulate the action of several monoamine, peptide and aminoacid neurotransmitters orticoid effects on the brain are likely to occur via receptor-mediated regulation of the rate of transcription of a set of genes 2,3,4.
Glucocorticoids receptors are expressed by nearly all cells in the body, yet the effects of glucocorticoids vary by cell type. The production of endogenous glucocorticoids is regulated by the.
Glucocorticoid Action on Rat Thymus Cells INTERRELATIONSHIPS BETWEEN CARBOHYDRATE, PROTEIN, AND ADENINE NUCLEOTIDE ME- TABOLISM AND CORTISOL EFFECTS ON THESE FUNCTIONS IN VITRO* (Received for publication, November 7, ) DONALD A. YOUNG.The Mechanism of Glucocorticoid Effects in Fibroblasts.
Changes in cortisol binding to soluble receptor proteins in rat liver and thymus during development and ageing. Some properties of cortisol-receptor complex isolated from cytoplasm of rat liver and its effect on biosynthesis of nuclear RNA.
Steroids22 (2).Kraml J., Kolínská J., Kadlecová L., Zákostelecká M., Hirsová D., Schreiber V. () The Effect of an Anti-Glucocorticoid (ZK ) on Thymus Evolution and on Hydrocortisone-Induced Thymolysis, Intestinal Brush-Border Enzymes and Their Desialylation in Suckling Rats.